Mississippi Chicken Casserole Recipe

Discover the ultimate comfort food with our Mississippi Chicken Casserole Recipe. Packed with tender chicken, creamy cheese, and savory spices! This is a family favorite for busy weeknights. 

Anytime I know that we're going to have a busy weekend, this easy recipe is on my radar. Not only are the ingredients simple to grab at the grocery store, but the egg noodles provide a heartiness to every bite that gives everyone the energy for the week. And most times, there is some leftover to enjoy the next day, meaning that it's less to plan and cook for. 

While a lot of people make this as a slow cooker recipe, I prefer to use a baking dish and oven. That way, I can change the flavors as I want and keep an eye on it since it has a faster cooking time. I think you'll agree that this easy chicken dinner recipe, as written on the recipe card below, is a winner. 

Whipping up this Mississippi Chicken Recipe is a fast and simple recipe that the whole family will love. This is one of these chicken recipes that make an easy meal using simple ingredients. Get ready to love the flavorful chicken in this creamy casserole. 

Be sure to check out my Chicken Poblano Casserole Recipe for another delicious chicken recipe that is sure to delight you. 

Ingredients 

Egg noodles - I love using egg noodles because they're thicker noodle that pairs really well with the rest of the casserole texture. 

Cooked chicken - Save yourself some time and buy chicken that is already prepped and ready. Or cook up some boneless skinless chicken breasts or thighs and shred.

Pepperoncini peppers - These add a nice pop of flavor without adding any heat. 

Cream cheese - Adding cream cheese helps to make the casserole dish creamy and not dry. 

Sour cream - The sour cream also helps with adding moisture and flavor. 

Salted butter - If you only have unsalted butter to use, just add a tad bit of salt. 

Pepper juice - This is the juice from the jar of tangy pepperoncini peppers. 

Ranch seasoning mix - Ranch dressing mix is simple to stir in for flavor. 

Au jus gravy mix - Au jus mix helps to thicken the casserole a bit without being overly thick. 

How to Make This Mississippi Chicken Casserole Recipe

Step One: Preheat the oven to 350 degrees. Grease a 9X13 baking dish.

Step Two: Put the egg noodles in a baking dish. 

Step Three: Add the cream cheese, sour cream, butter, juice, and seasonings in a bowl.

Step Four: Fold in the cooked chicken and the peppers. Spread this on top of the noodles. 

Step Five: Bake in the oven for 25-30 minutes or until hot and bubbly. 

Variations 

Use pot roast - While I love the flavor of this easy chicken recipe, you could also use cooked pot roast as well. This delicious recipe is versatile and simple to make with either protein option. Or try both the chicken version and a chuck roast version.

Add cream of chicken soup - If you want to add more flavor to this delicious dinner, you can add a tad bit of cream of chicken soup. 

Top with cheese - While the recipe does have cream cheese in it, you can add provolone cheese on top as well. It pairs really well with the pepperoncini peppers because they're mild peppers, not spicy. 

Add vegetables - You can add green beans, more banana peppers, green bell peppers, or any other ingredients that you want. Easy dinner recipes like this can be altered for picky eaters. 

Common Questions 

How do I serve this chicken casserole recipe? 

I like to make this for fun occasions like a game day or a family gathering. The large casserole dish proves that it can feed a ton of people with ease. For side dishes, you can serve on a bed of rice or even pour a little bit in a sandwich bun to make a yummy recipe. 

Can I make this into a crockpot Mississippi chicken?

Yes, add uncooked chicken and the rest of the ingredients (except the noodles) to a crock pot and cook on low for 6-8 hours. Once the slow cooker is almost done cook the pasta as directed on the box and serve on the side.

Can I make this spicier? 

If you want to add more peppers, go for it. You can also serve them on the side just in case other people don't like it as spicy.

What type of chicken should I use? 

If you want to make and cook tender chicken breasts, you can do so and then shred and add. Make sure that you use an instant-read thermometer to verify that the chicken is fully cooked to 160 degrees. I prefer to let them rest to come up to 165 degrees because if you keep them in the oven until 165 they may overcook as they rest.

We prefer to use boneless skinless chicken thighs in this recipe.

If you want to save on time, use leftover cooked chicken or buy rotisserie chicken from the store to use.